- Professor of Molecular Virology, CU Dept of Medicine
Professor Sinclair’s research interests are in the molecular biology and pathogenesis of human herpes viruses, particularly human cytomegalovirus (HCMV). HCMV is a major cause of disease in transplant patients, patients with AIDS as well as pregnant mothers and his research programme aims to understand latency and reactivation of this persistent human virus and how the host immune response combats virus disease.
An important aspect of persistence of this virus in the human is the mechanisms by which the virus prevents cell death from occurring before the virus has completed its relatively long life cycle – it encodes a number of genes to prevent cell death. These pro-life/anti-death genes may act as novel therapeutics to prevent neurodegeneration.
Professor Sinclair is an elected member of council of the Society for General Microbiology and a member of the American Society for Microbiology. He is also an editor of The Journal of General Virology and an Editorial Board member for the Journal of Virology.