- Professor of Cancer Research Cell Biology & Deputy Head of Department, CU Dept of Oncology
Gillian Murphy gained her PhD in the Dept of Biochemistry at Birmingham University and then completed a NATO Royal Society Fellowship with Professor Dr Feoder Lynen at the Max Planck Institute at Martinsried bei Muenchen. She joined the Strangeways Research Laboratory in Cambridge as a Postdoctoral Research Associate and later became an Arthritis Research Campaign senior fellow and Head of Dept. In 1997 she became Professor of Cell Biology at University of East Anglia (UEA), Norwich before joining the Dept of Oncology in Cambridge in 2002 as Chair of Cancer Cell Biology.
The Murphy Group’s research is currently focused on cell surface associated forms of the zinc-dependent proteinases, notably the membrane type matrix metalloproteinases (MT MMPs) and the disintegrin-type metalloproteinases (ADAMs), and the natural inhibitors that control them, the tissue inhibitors of metalloproteinases, TIMPs. We aim to elucidate how these metalloproteinases and inhibitors function and what their importance is as effectors of both physiological processes and pathologies, such as cancer. The development of novel reagents for disease therapy and diagnosis will emerge from the fundamental data accrued.