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BSc MSc PhD
Maria is currently a Senior Research Associate at the Department of Pharmacology, University of Cambridge. In October 2022, she became a Group Leader in the same department with the support of a Royal Society University Research Fellowship.
After obtaining a PhD in Biomedicine at the Pompeu Fabra University of Barcelona (Spain) with the highest possible grade in 2015, under the joint supervision of Dr Manuel Pastor and Dr Jana Selent, Maria spent two years as a Postdoctoral Researcher in the group of Professor Peter Kolb at the Pharmaceutical Chemistry Department of the Philipps University Marburg (Germany).
Maria’s work focuses on using computational biology methods to better understand G protein-coupled receptors (GPCRs). These receptors are widely distributed in our bodies to detect external cues such as odours, hormones or neurotransmitters and start appropriate signalling responses inside our cells. Besides receiving such signals, these receptors are also targeted by the majority of drugs prescribed nowadays. When many of these drugs were discovered, however, there was no information available on how receptors were distributed in different tissues or how they differed in the population. This could help explain some of the side effects of current drugs or why individuals respond to some drugs differently. Maria's work is centred on addressing these issues using systems pharmacology approaches that combine information on GPCR genomics, structure, and signalling properties. Such multi-dimensional analyses can help us understand how different sources of variation in the GPCR signalling machinery can affect physiological and drug responses. This, in turn, can help foster more rational and personalized pharmacological treatments.
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