Hirak Patra by Fiona Gilsenan

Dr Hirak K Patra

PhD AFHEA

Hirak is working as a Marie Curie Fellow for developing theranostic (combined diagnosis and therapy in a single unit) nanomedicine to overcome critical heterogeneous system such as drug resistance, tissue/organ regeneration.

Hirak Patra by Fiona Gilsenan

Hirak is a talented individual who has shown strong commitment to research, having proactively chosen translational research in Nanomedicine as his PhD subject, following a first-class degree in Biochemistry. As a postdoctoral fellow he spent two formative years in Professor Anthony Turner’s laboratory at LiU, Sweden where he obtained broad exposure to cutting-edge research and the opportunity to acquire a wide range of translational bio-sensing approaches. This laid the foundation for his next career development training in regenerative medicine with Prof. May Griffith (currently at UMontreal, Canada) who is the originator of the biosynthetic artificial cornea. These two training periods, along with his PhD training, positioned him for his successful EU Fellowship on translational ‘Theranostics’, a combined approach for diagnosis and therapy within a single unit. He is designing of a new class of biomimetic zipper nano-architecture drug delivery systems for translational therapeutic applications.

His current approach on translational theranostics,  is never been tried and is completely new to the field to overcome critical heterogeneous biomedical problems such as drug resistance, tissue/organ regeneration and could have significant research impact and quality of life in UK and beyond. Wolfson College will also explore his unique research experiences and leadership skills for which he has been granted as Tier 1 exceptional Talent Migrant status by UK Home Office duly endorsed by Royal Academy of Engineering.

Research interests

Hirak's current research interest is to explore unique nanoscale interactions between chemistry and biology that happen in living system with experimental feedback to engineer new technologies to understand and solve existing fundamental challenges in natural and medical science.

He is developing a biochemical concept of ‘molecular concealing’ and engineering the nanosystems in such a way that it can sense internal physiological states (such as local pH, temperature, ionic strength). These can be triggered to do their respective functions and can be operated and controlled remotely.

He developed systems that can potentially monitor the path of a drug while travelling inside the body without touching the patient (Patra, H et al, MRIVisual OrderDisorder Micellar Nanostructures for Smart Cancer Theranostics, Advanced Healthcare Materials 3, 2014: 526-535) and can switch on and off as needed (Patra, H et al, On/off-switchable anti-neoplastic nanoarchitecture, Scientific Reports 5, 2015).

Outside his main biological research line, he developed a very simple idea using near infra-red fluorescence to understand the water nano-clusters. He has granted and filed with several US and international patents with his concept (Patra, Hirak K et al, US9354170 B2, PCT/IB2011/000733, US20120021453 A1, PCT/IB2010/001954, US20120206721 A1, WO2011135399 A1, US20110046489 A1, WO2012110842 A1, US9133450 B2, PCT/IB2012/000744, WO2013114149A1). This novel method will help in many disciplines beyond chemistry and biology. Hirak plans to convert these spectral signals to images, which could have the potential to open up an entirely new imaging avenue capable of functional imaging at the single cell study and deep tissue imaging non-invasively.