Sean Flynn

Dr Sean Flynn

BA (Mod) PhD

  • Position Governing Body Fellow Junior Research Fellow
  • School Clinical Medicine Cancer Research UK Cambridge Institute - CRUKCI
  • Email
  • Twitter @sflynn4
  • Department link CRUKCI

Sean is a Junior Research Fellow and was previously a PhD student at Wolfson College. His research at the CRUK Cambridge Institute focuses on DNA structure and gene regulation.

Sean Flynn

Sean graduated with a BA in Human Genetics from Trinity College Dublin in 2013, and received his PhD from the University of Cambridge in 2018. For his PhD with Professor Mario de Bono at the MRC Laboratory of Molecular Biology, he identified genes and pathways that function in the nervous system using the small model organism C. elegans.

In 2020 he joined Professor Shankar Balasubramanian’s lab as a postdoctoral research associate at the CRUK Cambridge Institute, and in 2021 he was awarded a Leverhulme Trust Early Career Fellowship to investigate the biological functions of alternative DNA structures in the human genome.

In addition to the well-known double helix, DNA can form alternative structures such as the 4-stranded quadruplex. Although most of our DNA adopts a double helix, thousands of sites quadruplex structures form in our genome, like knots on a piece of string. However, their functions are not well understood. Sean is interested in understanding the role of quadruplex DNA in basic biological processes and identifying mechanisms by which it regulates gene expression.

Sean is based at the Cancer Research UK Cambridge Institute, where he uses genetic and genomics methods to study G-quadruplexes in human cells. He also works closely with colleagues at the Department of Chemistry.

What's on

Image 'Barbarians under the rug' by Enej Gala

Art Exhibition: 'After News Before Bed'

24/02/2024 at 10.00

Visit Wolfson's latest exhibition 'After News Before Bed' featuring work by emerging artist Enej Gala, winner of the Wolfson Royal Academy Schools Graduate Prize.

Painting of people on a harbour in the 1820s

The Age of Revolutions in Southern Europe

27/02/2024 at 17.30

What is a revolution? What role did Southern Europe play in the history of modern politics?

Advert for writing poems

Creative Poetry Workshop

28/02/2024 at 19.00

‘Poetry is everywhere; it just needs editing’, James Tate

Paper faces of all different colours.

The Place of Islamophobia within Debates on Racism

29/02/2024 at 17.30

This event is the second of three roundtables that Wolfson's REACH Research Hub will be organising over the academic year under the heading ‘Hierarchies of Racism?’