Science Society: Going back in time to trace how bacterial pathogens fast-tracked drug resistance evolution

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Dr Adrián Cazares ESPOD Research Fellow at EMBL-EBI and the Sanger Institute and Junior Research Fellow at Wolfson College
Date 17/06/2022 at 17.45 - 17/06/2022 at 19.00 Where Roger Needham room (Chancellor's Centre)

Antibiotic resistance is one of the greatest threats to global health, but its evolutionary process is one that we are far from understanding.

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How can we use sequencing, computational methods and historical archives to decipher how bacteria have adapted to survive antibiotic usage and what lessons can we learn from reconstructing 100-year-old genomes?

Antibiotic resistance is indisputably one of the greatest health crises in human history, driven by pathogens readily outpacing our ability to develop drugs able to kill them. In this talk, Dr Adrián Cazares will discuss why the emergence of resistance is an evolutionary process that we are far from understanding, and the relevance of learning the mechanisms allowing bacteria to develop resistance.

He will also present the efforts to combine state-of-the-art sequencing, computational methods and historical archives to decipher how bacteria have adapted to survive decades of antibiotics usage in the clinic, and the lessons we can learn from reconstructing 100-year-old genomes.

A Wolfson Junior Research Fellow, Adrián Cazares is a microbiologist and genomicist interested in the evolution of bacterial pathogens and their mobile genetic elements. He is also an ESPOD Research Fellow at EMBL-EBI and the Sanger Institute.