Science Society - Biotransformation: Learning Nature's Art of Unmaking Drugs to Sustainably Make New Drugs

Godwin Aleku
Godwin Aleku
Date 15/10/2021 at 18.00 - 15/10/2021 at 19.00 Where Gatsby Room, Chancellor's Centre

The Science Society organises regular talks during term time. Talks take place as as hybrid meetings, make sure to register if you plan to attend via Zoom.

Godwin Aleku

Biological systems of the human body as well as those of other living organisms are vastly experienced in the art of making biological molecules with utmost precision. They often employ enzymes as biological catalysts (biocatalysts) to construct simple to complex essential organic (bio)molecules.

Importantly, when challenged with synthetic compounds such as pharmaceutical drugs or xenobiotics, there are specialized enzymatic systems to unmake and eliminate these drugs. This process involves efficient and selective enzymatic modification (biotransformation) of important structural component(s) of the foreign compounds, often making them inactive and readily excretable.

The intriguing chemistry associated with this process as well as the chemical transformations catalysed by these enzymes are of great relevance in synthetic organic chemistry and can be developed and exploited for sustainable pharmaceutical synthesis.

In this lecture, using examples from the lab, Dr Godwin Aleku will highlight the power of biocatalysis (enzymatic synthesis) in the sustainable synthesis of pharmaceutical drugs with a particular emphasis on chiral amine-based pharmaceuticals.

Register to attend via zoom.

No registration required for in-person attendance.